NFL scores · Lucas Oil Stadium
TEAM1234T
SF1410101448
IND7103727
San Francisco 49ers
| SAN FRANCISCO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Brock Purdy | 25/34 | 295 | 8.7 | 5 | 1 | 1-0 | 88.6 | 126.8 |
| Team | 25/34 | 295 | 8.7 | 5 | 1 | 1-0 | -- | 126.8 |
| SAN FRANCISCO RUSHING | CAR | YDS | AVG | TD | LONG |
| Christian McCaffrey | 21 | 117 | 5.6 | 0 | 24 |
| Brian Robinson Jr. | 5 | 20 | 4.0 | 0 | 11 |
| Brock Purdy | 2 | 11 | 5.5 | 0 | 9 |
| Mac Jones | 3 | -3 | -1.0 | 0 | -1 |
| Team | 31 | 145 | 4.7 | 0 | 24 |
| SAN FRANCISCO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| George Kittle | 7 | 115 | 16.4 | 1 | 26 | 8 |
| Jauan Jennings | 5 | 71 | 14.2 | 1 | 21 | 6 |
| Christian McCaffrey | 6 | 29 | 4.8 | 2 | 10 | 8 |
| Kendrick Bourne | 3 | 27 | 9.0 | 0 | 14 | 5 |
| Demarcus Robinson | 2 | 23 | 11.5 | 1 | 22 | 2 |
| Skyy Moore | 1 | 23 | 23.0 | 0 | 23 | 1 |
| Jake Tonges | 1 | 7 | 7.0 | 0 | 7 | 2 |
| Brian Robinson Jr. | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Team | 25 | 295 | 11.8 | 5 | 26 | 33 |
| SAN FRANCISCO FUMBLES | FUM | LOST | REC |
| Brock Purdy | 1 | 0 | 0 |
| Luke Farrell | 0 | 0 | 1 |
| Jake Tonges | 0 | 0 | 1 |
| Team | 1 | 0 | 2 |
| SAN FRANCISCO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Ji'Ayir Brown | 9 | 5 | 0 | 1 | 0 | 0 | 0 |
| Tatum Bethune | 9 | 4 | 0 | 0 | 1 | 0 | 0 |
| Malik Mustapha | 8 | 3 | 0 | 0 | 0 | 1 | 0 |
| Darrell Luter Jr. | 6 | 5 | 0 | 0 | 1 | 0 | 0 |
| Upton Stout | 6 | 3 | 0 | 0 | 2 | 0 | 0 |
| Deommodore Lenoir | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Keion White | 3 | 1 | 0 | 0 | 0 | 1 | 0 |
| Dee Winters | 3 | 1 | 0 | 0 | 2 | 0 | 1 |
| Sam Okuayinonu | 3 | 1 | 0 | 0 | 0 | 0 | 0 |
| Kalia Davis | 3 | 0 | 0 | 0 | 1 | 0 | 0 |
| Jake Tonges | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Alfred Collins | 2 |
| SAN FRANCISCO INTERCEPTIONS | INT | YDS | TD |
| Dee Winters | 1 | 74 | 1 |
| Team | 1 | 74 | 1 |
| SAN FRANCISCO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Skyy Moore | 4 | 112 | 28.0 | 36 | 0 |
| Brian Robinson Jr. | 2 | 55 | 27.5 | 31 | 0 |
| Team | 6 | 167 | 27.8 | 36 | 0 |
| SAN FRANCISCO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Skyy Moore | 1 | 8 | 8.0 | 8 | 0 |
| Team | 1 | 8 | 8.0 | 8 | 0 |
| SAN FRANCISCO KICKING | FG | PCT | LONG | XP | PTS |
| Eddy Pineiro | 2/3 | 66.7 | 38 | 6/6 | 12 |
| Team | 2/3 | 66.7 | 38 | 6/6 | 12 |
| SAN FRANCISCO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
Indianapolis Colts
| INDIANAPOLIS PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Philip Rivers | 23/35 | 277 | 7.9 | 2 | 1 | 2-23 | 52.2 | 97.0 |
| Riley Leonard | 0/1 | 0 | 0.0 | 0 | 0 | 0-0 | 2.2 | 39.6 |
| Team | 23/36 | 254 | 7.7 | 2 | 1 | 2-23 | -- | 94.3 |
| INDIANAPOLIS RUSHING | CAR | YDS | AVG | TD | LONG |
| Jonathan Taylor | 16 | 46 | 2.9 | 1 | 7 |
| Tyler Goodson | 3 | 9 | 3.0 | 0 | 6 |
| Josh Downs | 1 | 3 | 3.0 | 0 | 3 |
| Team | 20 | 58 | 2.9 | 1 | 7 |
| INDIANAPOLIS RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Alec Pierce | 4 | 86 | 21.5 | 2 | 33 | 4 |
| Josh Downs | 5 |