| SEATTLE PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Geno Smith | 24/30 | 197 | 6.6 | 0 | 1 | 2-17 | 56.4 | 80.1 |
| DeeJay Dallas | 0/1 | 0 | 0.0 | 0 | 1 | 0-0 | 0.0 | 0.0 |
| Team | 24/31 | 180 | 6.4 | 0 | 2 | 2-17 | -- | 80.1 |
| SEATTLE RUSHING | CAR | YDS | AVG | TD | LONG |
| Rashaad Penny | 6 | 15 | 2.5 | 0 | 6 |
| Kenneth Walker III | 4 | 10 | 2.5 | 0 | 8 |
| Travis Homer | 2 | 9 | 4.5 | 0 | 5 |
| Geno Smith | 2 | 2 | 1.0 | 0 | 3 |
| Team | 14 | 36 | 2.6 | 0 | 8 |
| SEATTLE RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Tyler Lockett | 9 | 107 | 11.9 | 0 | 27 | 11 |
| DK Metcalf | 4 | 35 | 8.8 | 0 | 12 | 6 |
| Travis Homer | 4 | 33 | 8.3 | 0 | 17 | 4 |
| Noah Fant | 2 | 11 | 5.5 | 0 | 7 | 2 |
| Dee Eskridge | 1 | 6 | 6.0 | 0 | 6 | 1 |
| Kenneth Walker III | 2 | 5 | 2.5 | 0 | 3 | 3 |
| Marquise Goodwin | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Will Dissly | 2 | 0 | 0.0 | 0 | 2 | 2 |
| Team | 24 | 197 | 8.2 | 0 | 27 | 30 |
| SEATTLE FUMBLES | FUM | LOST | REC |
| Xavier Crawford | 1 | 1 | 0 |
| Team | 1 | 1 | 0 |
| SEATTLE DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Jordyn Brooks | 11 | 7 | 0 | 0 | 0 | 0 | 0 |
| Cody Barton | 11 | 4 | 0 | 0 | 0 | 0 | 0 |
| Al Woods | 7 | 6 | 0 | 3 | 1 | 0 | 0 |
| Quandre Diggs | 6 | 5 | 0 | 0 | 0 | 0 | 0 |
| Mike Jackson | 6 | 5 | 0 | 0 | 0 | 0 | 1 |
| Coby Bryant | 5 | 4 | 0 | 0 | 0 | 0 | 0 |
| Boye Mafe | 4 | 4 | 1 | 1 | 0 | 1 | 0 |
| Josh Jones | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Bryan Mone | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Uchenna Nwosu | 3 | 3 | 0 | 0 | 1 | 3 | 0 |
| Darrell Taylor | 3 | 3 | 0 | 2 | 0 | 0 | 0 |
| Riq Woolen | 3 | 3 | 0 | 0 | 0 |
| SEATTLE INTERCEPTIONS | INT | YDS | TD |
| SEATTLE KICK RETURNS | NO | YDS | AVG | LONG | TD |
| DeeJay Dallas | 3 | 46 | 15.3 | 16 | 0 |
| Team | 3 | 46 | 15.3 | 16 | 0 |
| SEATTLE PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Xavier Crawford | 1 | 0 | 0.0 | 0 | 0 |
| Team | 1 | 0 | 0.0 | 0 | 0 |
| SEATTLE KICKING | FG | PCT | LONG | XP | PTS |
| Jason Myers | 0/0 | 0.0 | 0 | 1/1 | 1 |
| Team | 0/0 | 0.0 | 0 | 1/1 | 1 |
| SEATTLE PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Michael Dickson | 5 | 249 | 49.8 | 0 | 1 | 54 |
| Team | 5 | 249 | 49.8 | 0 | 1 | 54 |
| SAN FRANCISCO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Jimmy Garoppolo | 13/21 | 154 | 7.3 | 1 | 0 | 1-0 | 66.7 | 100.1 |
| Trey Lance | 2/3 | 30 | 10.0 | 0 | 0 | 0-0 | 57.6 | 99.3 |
| Team | 15/24 | 184 | 7.7 | 1 | 0 | 1-0 | -- | 100.0 |
| SAN FRANCISCO RUSHING | CAR | YDS | AVG | TD | LONG |
| Jeff Wilson Jr. | 18 | 84 | 4.7 | 0 | 16 |
| Deebo Samuel Sr. | 4 | 53 | 13.3 | 0 | 51 |
| Tyrion Davis-Price | 14 | 33 | 2.4 | 0 | 20 |
| Trey Lance | 3 | 13 | 4.3 | 0 | 7 |
| Jimmy Garoppolo | 4 | 5 | 1.3 | 1 | 3 |
| Kyle Juszczyk | 2 | 1 | 0.5 | 1 | 1 |
| Team | 45 | 189 | 4.2 | 2 | 51 |
| 0 |
| 0 |
| Nick Bellore | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Poona Ford | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Darryl Johnson | 2 | 2 | 0 | 1 | 0 | 0 | 0 |
| Quinton Jefferson | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
| Will Dissly | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| DeeJay Dallas | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Team | 77 | 58 | 1 | 7 | 2 | 4 | 1 |
| SAN FRANCISCO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Brandon Aiyuk | 5 | 63 | 12.6 | 0 | 25 | 8 |
| Deebo Samuel Sr. | 5 | 44 | 8.8 | 0 | 15 | 6 |
| Ross Dwelley | 1 | 38 | 38.0 | 1 | 38 | 1 |
| Jeff Wilson Jr. | 2 | 19 | 9.5 | 0 | 14 | 2 |
| Ray-Ray McCloud III | 1 | 16 | 16.0 | 0 | 16 | 2 |
| Jauan Jennings | 1 | 4 | 4.0 | 0 | 4 | 2 |
| Kyle Juszczyk | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Danny Gray | 0 | 0 | 0.0 | 0 | 0 | 2 |
| Team | 15 | 184 | 12.3 | 1 | 38 | 24 |
| SAN FRANCISCO FUMBLES | FUM | LOST | REC |
| Jake Brendel | 1 | 0 | 0 |
| Deebo Samuel Sr. | 1 | 0 | 1 |
| Ross Dwelley | 0 | 0 | 2 |
| Team | 2 | 0 | 3 |
| SAN FRANCISCO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Dre Greenlaw | 8 | 6 | 0 | 1 | 0 | 0 | 0 |
| Charvarius Ward | 8 | 4 | 0 | 0 | 1 | 0 | 0 |
| Talanoa Hufanga | 6 | 5 | 0 | 1 | 2 | 0 | 0 |
| Nick Bosa | 4 | 4 | 2 | 2 | 0 | 5 | 0 |
| Kevin Givens | 4 | 3 | 0 | 3 | 0 | 0 | 0 |
| Emmanuel Moseley | 3 | 3 | 0 | 0 | 1 | 0 | 0 |
| Samson Ebukam | 3 | 2 | 0 | 0 | 0 | 1 | 0 |
| Samuel Womack III | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Fred Warner | 3 | 1 | 0 | 0 | 0 | 0 | 0 |
| Tashaun Gipson Sr. | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
| Arik Armstead | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| George Odum | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Javon Kinlaw | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Oren Burks | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Azeez Al-Shaair | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Charles Omenihu | 1 | 0 | 0 | 0 | 0 | 2 | 0 |
| Deommodore Lenoir | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ambry Thomas | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jordan Mason | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Hassan Ridgeway | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Team | 52 | 34 | 2 | 7 | 5 | 9 | 0 |
| SAN FRANCISCO INTERCEPTIONS | INT | YDS | TD |
| Tashaun Gipson Sr. | 1 | 14 | 0 |
| Charvarius Ward | 1 | 9 | 0 |
| Team | 2 | 23 | 0 |
| SAN FRANCISCO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| SAN FRANCISCO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Ray-Ray McCloud III | 3 | 23 | 7.7 | 14 | 0 |
| Team | 3 | 23 | 7.7 | 14 | 0 |
| SAN FRANCISCO KICKING | FG | PCT | LONG | XP | PTS |
| Robbie Gould | 2/3 | 67.0 | 33 | 3/3 | 9 |
| Team | 2/3 | 66.7 | 33 | 3/3 | 9 |
| SAN FRANCISCO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Mitch Wishnowsky | 3 | 132 | 44.0 | 0 | 2 | 47 |
| Team | 3 | 132 | 44.0 | 0 | 2 | 47 |