| SAN FRANCISCO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Jimmy Garoppolo | 26/35 | 322 | 9.2 | 1 | 2 | 2-16 | 53.0 | 88.0 |
| Team | 26/35 | 306 | 9.2 | 1 | 2 | 2-16 | -- | 88.0 |
| SAN FRANCISCO RUSHING | CAR | YDS | AVG | TD | LONG |
| Jeff Wilson Jr. | 14 | 45 | 3.2 | 1 | 9 |
| Deebo Samuel Sr. | 5 | 32 | 6.4 | 0 | 12 |
| Jimmy Garoppolo | 1 | 3 | 3.0 | 0 | 3 |
| JaMycal Hasty | 1 | 3 | 3.0 | 0 | 3 |
| Team | 21 | 83 | 4.0 | 1 | 12 |
| SAN FRANCISCO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Deebo Samuel Sr. | 9 | 159 | 17.7 | 0 | 56 | 11 |
| Kyle Juszczyk | 3 | 45 | 15.0 | 0 | 26 | 5 |
| Brandon Aiyuk | 4 | 40 | 10.0 | 1 | 17 | 5 |
| JaMycal Hasty | 3 | 26 | 8.7 | 0 | 12 | 3 |
| George Kittle | 2 | 21 | 10.5 | 0 | 16 | 3 |
| Jauan Jennings | 2 | 19 | 9.5 | 0 | 11 | 5 |
| Jeff Wilson Jr. | 3 | 12 | 4.0 | 0 | 11 | 3 |
| Team | 26 | 322 | 12.4 | 1 | 56 | 35 |
| SAN FRANCISCO FUMBLES | FUM | LOST | REC |
| Deebo Samuel Sr. | 2 | 0 | 1 |
| JaMycal Hasty | 1 | 0 | 0 |
| Brandon Aiyuk | 0 | 0 | 1 |
| Team | 3 | 0 | 2 |
| SAN FRANCISCO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Jaquiski Tartt | 6 | 5 | 0 | 1 | 0 | 0 | 0 |
| Fred Warner | 6 | 5 | 0 | 1 | 0 | 0 | 0 |
| Azeez Al-Shaair | 6 | 1 | 0.5 | 0 | 0 | 1 | 0 |
| Marcell Harris | 4 | 4 | 0 | 0 | 0 | 0 | 0 |
| Samson Ebukam | 4 | 3 | 1.5 | 1 | 0 | 2 | 0 |
| K'Waun Williams | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Josh Norman | 4 | 2 | 0 | 0 | 0 | 0 | 0 |
| Kentavius Street | 3 | 3 | 1 | 2 | 0 | 1 | 0 |
| Jimmie Ward | 3 | 3 | 0 | 0 | 2 | 0 | 0 |
| D.J. Jones | 3 | 3 | 0 | 1 | 0 | 1 | 0 |
| Nick Bosa | 3 | 3 | 0 | 1 | 0 | 1 | 0 |
| Arik Armstead | 3 | 2 |
| SAN FRANCISCO INTERCEPTIONS | INT | YDS | TD |
| SAN FRANCISCO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| SAN FRANCISCO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Brandon Aiyuk | 1 | 12 | 12.0 | 12 | 0 |
| Team | 1 | 12 | 12.0 | 12 | 0 |
| SAN FRANCISCO KICKING | FG | PCT | LONG | XP | PTS |
| Robbie Gould | 1/1 | 100.0 | 48 | 2/2 | 5 |
| Team | 1/1 | 100.0 | 48 | 2/2 | 5 |
| SAN FRANCISCO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Mitch Wishnowsky | 2 | 70 | 35.0 | 0 | 1 | 40 |
| Team | 2 | 70 | 35.0 | 0 | 1 | 40 |
| TENNESSEE PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Ryan Tannehill | 22/29 | 209 | 7.2 | 1 | 0 | 4-21 | 80.4 | 106.8 |
| A.J. Brown | 0/1 | 0 | 0.0 | 0 | 0 | 0-0 | 4.4 | 39.6 |
| Team | 22/30 | 188 | 7.0 | 1 | 0 | 4-21 | -- | 103.3 |
| TENNESSEE RUSHING | CAR | YDS | AVG | TD | LONG |
| Jeremy McNichols | 7 | 31 | 4.4 | 0 | 10 |
| Ryan Tannehill | 3 | 22 | 7.3 | 0 | 23 |
| Dontrell Hilliard | 5 | 20 | 4.0 | 0 | 9 |
| D'Onta Foreman | 9 | 17 | 1.9 | 1 | 8 |
| Team | 24 | 90 | 3.8 | 1 | 23 |
| TENNESSEE RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| A.J. Brown | 11 | 145 | 13.2 |
| 0 |
| 1 |
| 0 |
| 1 |
| 0 |
| Kevin Givens | 3 | 0 | 0 | 0 | 0 | 0 | 0 |
| Jarrod Wilson | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Jordan Willis | 2 | 1 | 1 | 1 | 0 | 1 | 0 |
| Trent Sherfield | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Deebo Samuel Sr. | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Charles Omenihu | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Ambry Thomas | 1 | 1 | 0 | 0 | 2 | 0 | 0 |
| Arden Key | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
| Team | 61 | 44 | 4 | 9 | 4 | 9 | 0 |
| 1 |
| 42 |
| 16 |
| Nick Westbrook-Ikhine | 2 | 38 | 19.0 | 0 | 24 | 3 |
| Anthony Firkser | 1 | 13 | 13.0 | 0 | 13 | 1 |
| Geoff Swaim | 3 | 10 | 3.3 | 0 | 6 | 3 |
| Julio Jones | 1 | 7 | 7.0 | 0 | 7 | 1 |
| Chester Rogers | 1 | 3 | 3.0 | 0 | 3 | 1 |
| Jeremy McNichols | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Racey McMath | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Khari Blasingame | 1 | -1 | -1.0 | 0 | -1 | 1 |
| Dontrell Hilliard | 2 | -6 | -3.0 | 0 | 2 | 2 |
| Team | 22 | 209 | 9.5 | 1 | 42 | 30 |
| TENNESSEE FUMBLES | FUM | LOST | REC |
| TENNESSEE DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Rashaan Evans | 7 | 5 | 0 | 0 | 0 | 0 | 0 |
| Buster Skrine | 7 | 3 | 0 | 0 | 0 | 0 | 0 |
| Kevin Byard | 6 | 4 | 0 | 0 | 0 | 1 | 0 |
| Amani Hooker | 6 | 2 | 0 | 0 | 1 | 0 | 0 |
| Naquan Jones | 5 | 3 | 0 | 0 | 1 | 0 | 0 |
| Jayon Brown | 5 | 2 | 0 | 0 | 0 | 0 | 0 |
| Zach Cunningham | 4 | 4 | 0 | 1 | 0 | 0 | 0 |
| Bud Dupree | 4 | 3 | 1 | 1 | 0 | 1 | 0 |
| Dane Cruikshank | 4 | 2 | 0 | 0 | 0 | 0 | 0 |
| Denico Autry | 3 | 2 | 1 | 1 | 0 | 1 | 0 |
| Harold Landry III | 3 | 1 | 0 | 0 | 0 | 0 | 0 |
| Kyle Peko | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Jeffery Simmons | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Kristian Fulton | 2 | 1 | 0 | 0 | 1 | 0 | 0 |
| Dylan Cole | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Janoris Jenkins | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
| Team | 62 | 37 | 2 | 3 | 4 | 3 | 0 |
| TENNESSEE INTERCEPTIONS | INT | YDS | TD |
| Amani Hooker | 1 | 21 | 0 |
| Janoris Jenkins | 1 | 0 | 0 |
| Team | 2 | 21 | 0 |
| TENNESSEE KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Chester Rogers | 2 | 57 | 28.5 | 37 | 0 |
| Team | 2 | 57 | 28.5 | 37 | 0 |
| TENNESSEE PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| TENNESSEE KICKING | FG | PCT | LONG | XP | PTS |
| Randy Bullock | 2/2 | 100.0 | 44 | 2/2 | 8 |
| Team | 2/2 | 100.0 | 44 | 2/2 | 8 |
| TENNESSEE PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Brett Kern | 5 | 230 | 46.0 | 1 | 2 | 59 |
| Team | 5 | 230 | 46.0 | 1 | 2 | 59 |