| SAN FRANCISCO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Jimmy Garoppolo | 17/25 | 314 | 12.6 | 1 | 0 | 1-8 | 75.6 | 124.2 |
| Trey Lance | 1/1 | 5 | 5.0 | 1 | 0 | 0-0 | 8.3 | 127.1 |
| Team | 18/26 | 311 | 12.3 | 2 | 0 | 1-8 | -- | 136.5 |
| SAN FRANCISCO RUSHING | CAR | YDS | AVG | TD | LONG |
| Elijah Mitchell | 19 | 104 | 5.5 | 1 | 38 |
| Raheem Mostert | 2 | 20 | 10.0 | 0 | 11 |
| JaMycal Hasty | 1 | 3 | 3.0 | 1 | 3 |
| Jimmy Garoppolo | 3 | 2 | 0.7 | 0 | 3 |
| Trey Lance | 3 | 2 | 0.7 | 0 | 2 |
| Team | 28 | 131 | 4.7 | 2 | 38 |
| SAN FRANCISCO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Deebo Samuel Sr. | 9 | 189 | 21.0 | 1 | 79 | 12 |
| George Kittle | 4 | 78 | 19.5 | 0 | 35 | 5 |
| Trent Sherfield | 2 | 23 | 11.5 | 1 | 18 | 3 |
| JaMycal Hasty | 1 | 15 | 15.0 | 0 | 15 | 1 |
| Mohamed Sanu | 1 | 7 | 7.0 | 0 | 7 | 1 |
| Kyle Juszczyk | 1 | 7 | 7.0 | 0 | 7 | 1 |
| Team | 18 | 319 | 17.7 | 2 | 79 | 23 |
| SAN FRANCISCO FUMBLES | FUM | LOST | REC |
| Jimmy Garoppolo | 1 | 1 | 0 |
| Deebo Samuel Sr. | 1 | 1 | 0 |
| Team | 2 | 2 | 0 |
| SAN FRANCISCO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Fred Warner | 11 | 7 | 0 | 0 | 0 | 0 | 0 |
| Jaquiski Tartt | 7 | 5 | 0 | 2 | 0 | 0 | 0 |
| Azeez Al-Shaair | 7 | 4 | 0 | 2 | 2 | 0 | 0 |
| Jimmie Ward | 6 | 4 | 0 | 0 | 0 | 0 | 0 |
| Dre Greenlaw | 6 | 4 | 0 | 0 | 1 | 0 | 1 |
| Jason Verrett | 5 | 3 | 0 | 0 | 0 | 0 | 0 |
| Samson Ebukam | 5 | 2 | 0 | 0 | 0 | 1 | 0 |
| Nick Bosa | 4 | 4 | 1 | 3 | 0 | 2 | 0 |
| Dontae Johnson | 3 | 2 | 0 | 0 | 1 | 0 | 0 |
| K'Waun Williams | 3 | 2 | 0 | 0 | 0 | 1 | 0 |
| Demetrius Flannigan-Fowles | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Deommodore Lenoir | 3 | 2 |
| SAN FRANCISCO INTERCEPTIONS | INT | YDS | TD |
| Dre Greenlaw | 1 | 39 | 1 |
| Team | 1 | 39 | 1 |
| SAN FRANCISCO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Ambry Thomas | 4 | 70 | 17.5 | 19 | 0 |
| Team | 4 | 70 | 17.5 | 19 | 0 |
| SAN FRANCISCO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Mohamed Sanu | 1 | 11 | 11.0 | 11 | 0 |
| Brandon Aiyuk | 1 | 7 | 7.0 | 7 | 0 |
| Team | 2 | 18 | 9.0 | 11 | 0 |
| SAN FRANCISCO KICKING | FG | PCT | LONG | XP | PTS |
| Robbie Gould | 2/3 | 67.0 | 52 | 5/5 | 11 |
| Team | 2/3 | 66.7 | 52 | 5/5 | 11 |
| SAN FRANCISCO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Mitch Wishnowsky | 2 | 76 | 38.0 | 0 | 2 | 43 |
| Team | 2 | 76 | 38.0 | 0 | 2 | 43 |
| DETROIT PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Jared Goff | 38/57 | 338 | 5.9 | 3 | 1 | 3-24 | 32.1 | 92.6 |
| Team | 38/57 | 314 | 5.9 | 3 | 1 | 3-24 | -- | 92.6 |
| DETROIT RUSHING | CAR | YDS | AVG | TD | LONG |
| Jamaal Williams | 9 | 54 | 6.0 | 1 | 20 |
| D'Andre Swift | 11 | 39 | 3.5 | 0 | 16 |
| Jared Goff | 3 | 14 | 4.7 | 0 | 10 |
| Kalif Raymond | 1 | 9 | 9.0 | 0 | 9 |
| Team | 24 | 116 | 4.8 | 1 | 20 |
| DETROIT RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| T.J. Hockenson | 8 | 97 | 12.1 | 1 | 23 | 11 |
| D'Andre Swift | 8 | 65 | 8.1 | 1 | 43 | 11 |
| 0 |
| 0 |
| 0 |
| 0 |
| 0 |
| Kentavius Street | 3 | 1 | 1 | 1 | 0 | 2 | 0 |
| Ambry Thomas | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Marcell Harris | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Dee Ford | 1 | 1 | 1 | 1 | 0 | 2 | 0 |
| Tavon Wilson | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Arik Armstead | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
| Arden Key | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Kevin Givens | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Team | 75 | 49 | 3 | 9 | 4 | 9 | 1 |
| Jamaal Williams |
| 8 |
| 56 |
| 7.0 |
| 0 |
| 11 |
| 9 |
| Kalif Raymond | 3 | 50 | 16.7 | 0 | 25 | 4 |
| Amon-Ra St. Brown | 2 | 23 | 11.5 | 0 | 20 | 4 |
| Trinity Benson | 3 | 19 | 6.3 | 0 | 11 | 6 |
| Tyrell Williams | 2 | 14 | 7.0 | 0 | 7 | 3 |
| Quintez Cephus | 3 | 12 | 4.0 | 1 | 7 | 6 |
| Darren Fells | 1 | 2 | 2.0 | 0 | 2 | 1 |
| Jason Cabinda | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Team | 38 | 338 | 8.9 | 3 | 43 | 56 |
| DETROIT FUMBLES | FUM | LOST | REC |
| Jamie Collins Sr. | 0 | 0 | 1 |
| Ifeatu Melifonwu | 0 | 0 | 1 |
| Team | 0 | 0 | 2 |
| DETROIT DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Tracy Walker III | 7 | 6 | 1 | 1 | 0 | 1 | 0 |
| Will Harris | 7 | 4 | 0 | 0 | 0 | 0 | 0 |
| Michael Brockers | 5 | 3 | 0 | 0 | 0 | 0 | 0 |
| Jamie Collins Sr. | 5 | 3 | 0 | 0 | 0 | 1 | 0 |
| Trey Flowers | 4 | 4 | 0 | 0 | 0 | 0 | 0 |
| Jeff Okudah | 4 | 3 | 0 | 0 | 1 | 0 | 0 |
| Alex Anzalone | 4 | 2 | 0 | 0 | 0 | 0 | 0 |
| Alim McNeill | 4 | 2 | 0 | 0 | 0 | 0 | 0 |
| Kevin Strong | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
| Jerry Jacobs | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Jason Cabinda | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| AJ Parker | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Derrick Barnes | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Anthony Pittman | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Godwin Igwebuike | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Amani Oruwariye | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
| Nick Williams | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Romeo Okwara | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
| Jalen Reeves-Maybin | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Team | 58 | 38 | 1 | 1 | 2 | 3 | 0 |
| DETROIT INTERCEPTIONS | INT | YDS | TD |
| DETROIT KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Godwin Igwebuike | 4 | 55 | 13.8 | 27 | 0 |
| Team | 4 | 55 | 13.8 | 27 | 0 |
| DETROIT PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| DETROIT KICKING | FG | PCT | LONG | XP | PTS |
| Austin Seibert | 1/2 | 50.0 | 49 | 2/2 | 5 |
| Team | 1/2 | 50.0 | 49 | 2/2 | 5 |
| DETROIT PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Jack Fox | 3 | 152 | 50.7 | 0 | 1 | 57 |
| Team | 3 | 152 | 50.7 | 0 | 1 | 57 |