| BUFFALO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Josh Allen | 24/46 | 264 | 5.7 | 0 | 0 | 3-27 | 42.5 | 69.5 |
| John Brown | 1/1 | 16 | 16.0 | 1 | 0 | 0-0 | 100.0 | 158.3 |
| Corey Bojorquez | 0/1 | 0 | 0.0 | 0 | 0 | 0-0 | -- | 39.6 |
| Team | 25/48 | 253 | 5.8 | 1 | 0 | 3-27 | -- | 76.7 |
| BUFFALO RUSHING | CAR | YDS | AVG | TD | LONG |
| Josh Allen | 9 | 92 | 10.2 | 0 | 42 |
| Devin Singletary | 13 | 58 | 4.5 | 0 | 18 |
| Frank Gore | 8 | 22 | 2.8 | 0 | 14 |
| Team | 30 | 172 | 5.7 | 0 | 42 |
| BUFFALO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Devin Singletary | 6 | 76 | 12.7 | 0 | 38 | 7 |
| John Brown | 4 | 50 | 12.5 | 0 | 28 | 8 |
| Duke Williams | 4 | 49 | 12.3 | 0 | 20 | 10 |
| Cole Beasley | 4 | 44 | 11.0 | 0 | 21 | 5 |
| Isaiah McKenzie | 4 | 23 | 5.8 | 0 | 10 | 5 |
| Josh Allen | 1 | 16 | 16.0 | 1 | 16 | 1 |
| Dawson Knox | 1 | 14 | 14.0 | 0 | 14 | 2 |
| Lee Smith | 1 | 8 | 8.0 | 0 | 8 | 1 |
| Frank Gore | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Patrick DiMarco | 0 | 0 | 0.0 | 0 | 0 | 1 |
| Tyler Kroft | 0 | 0 | 0.0 | 0 | 0 | 2 |
| Team | 25 | 280 | 11.2 | 1 | 38 | 43 |
| BUFFALO FUMBLES | FUM | LOST | REC |
| Josh Allen | 2 | 1 | 0 |
| Tremaine Edmunds | 0 | 0 | 1 |
| Team | 2 | 1 | 1 |
| BUFFALO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Tremaine Edmunds | 12 | 8 | 1 | 1 | 0 | 2 | 0 |
| Matt Milano | 12 | 8 | 0 | 0 | 0 | 1 | 0 |
| Kevin Johnson | 9 | 7 | 0 | 0 | 0 | 0 | 0 |
| Trent Murphy | 6 | 4 | 2 | 1 | 0 | 2 | 0 |
| Jordan Poyer | 6 | 1 | 0 | 0 | 0 | 0 | 0 |
| Micah Hyde | 5 | 4 | 0 | 0 | 0 | 0 | 0 |
| Tre'Davious White | 5 | 4 | 0 | 0 | 0 | 0 | 0 |
| Jerry Hughes | 4 | 3 | 3 | 3 | 0 | 4 | 0 |
| Siran Neal | 4 | 3 | 1 | 1 | 1 | 1 | 0 |
| Ed Oliver | 4 | 0 | 0 | 0 | 0 | 0 | 0 |
| Lorenzo Alexander | 3 | 1 | 0 | 0 | 0 | 0 | 0 |
| Star Lotulelei | 2 | 2 | 0 | 0 | 0 |
| BUFFALO INTERCEPTIONS | INT | YDS | TD |
| BUFFALO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| BUFFALO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Andre Roberts | 1 | 8 | 8.0 | 8 | 0 |
| Team | 1 | 8 | 8.0 | 8 | 0 |
| BUFFALO KICKING | FG | PCT | LONG | XP | PTS |
| Stephen Hauschka | 4/4 | 100.0 | 47 | 1/1 | 13 |
| Team | 4/4 | 100.0 | 47 | 1/1 | 13 |
| BUFFALO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Corey Bojorquez | 4 | 179 | 44.8 | 1 | 1 | 56 |
| Team | 4 | 179 | 44.8 | 1 | 1 | 56 |
| HOUSTON PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Deshaun Watson | 20/25 | 247 | 9.9 | 1 | 0 | 7-28 | 60.4 | 121.2 |
| Team | 20/25 | 219 | 9.9 | 1 | 0 | 7-28 | -- | 121.2 |
| HOUSTON RUSHING | CAR | YDS | AVG | TD | LONG |
| Deshaun Watson | 14 | 55 | 3.9 | 1 | 20 |
| Carlos Hyde | 16 | 48 | 3.0 | 0 | 8 |
| Duke Johnson | 3 | 38 | 12.7 | 0 | 19 |
| Team | 33 | 141 | 4.3 | 1 | 20 |
| HOUSTON RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| DeAndre Hopkins | 6 | 90 | 15.0 | 0 | 41 | 8 |
| Kenny Stills | 4 | 46 | 11.5 | 0 | 20 | 5 |
| Darren Fells | 4 | 37 | 9.3 | 0 | 14 | 5 |
| 0 |
| 0 |
| Shaq Lawson | 2 | 2 | 0 | 0 | 0 | 1 | 0 |
| Julian Stanford | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Quinton Spain | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Jordan Phillips | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Taron Johnson | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
| Team | 76 | 49 | 7 | 6 | 2 | 12 | 0 |
| Taiwan Jones |
| 1 |
| 34 |
| 34.0 |
| 0 |
| 34 |
| 1 |
| Duke Johnson | 3 | 30 | 10.0 | 0 | 18 | 3 |
| Carlos Hyde | 1 | 5 | 5.0 | 1 | 5 | 1 |
| DeAndre Carter | 1 | 5 | 5.0 | 0 | 5 | 2 |
| Team | 20 | 247 | 12.4 | 1 | 41 | 25 |
| HOUSTON FUMBLES | FUM | LOST | REC |
| DeAndre Hopkins | 1 | 1 | 0 |
| Deshaun Watson | 1 | 0 | 0 |
| Jacob Martin | 0 | 0 | 1 |
| Team | 2 | 1 | 1 |
| HOUSTON DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Benardrick McKinney | 10 | 6 | 0 | 0 | 0 | 1 | 0 |
| Zach Cunningham | 9 | 5 | 0 | 1 | 1 | 0 | 0 |
| Bradley Roby | 7 | 7 | 0 | 0 | 2 | 0 | 0 |
| Justin Reid | 7 | 4 | 0 | 1 | 0 | 0 | 0 |
| Vernon Hargreaves III | 6 | 6 | 0 | 0 | 0 | 1 | 0 |
| Gareon Conley | 6 | 5 | 0 | 0 | 3 | 0 | 0 |
| DJ Reader | 6 | 3 | 0 | 0.5 | 0 | 0 | 0 |
| Mike Adams | 4 | 4 | 0 | 1 | 0 | 0 | 0 |
| Whitney Mercilus | 4 | 2 | 1 | 0 | 0 | 3 | 0 |
| Angelo Blackson | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| J.J. Watt | 2 | 1 | 1 | 1.5 | 0 | 2 | 0 |
| Jahleel Addae | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Brandon Dunn | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Brennan Scarlett | 2 | 1 | 0 | 0 | 0 | 1 | 0 |
| Jacob Martin | 1 | 1 | 1 | 1 | 0 | 2 | 0 |
| Cullen Gillaspia | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| A.J. Moore Jr. | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
| Charles Omenihu | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Team | 74 | 49 | 3 | 6 | 6 | 11 | 0 |
| HOUSTON INTERCEPTIONS | INT | YDS | TD |
| HOUSTON KICK RETURNS | NO | YDS | AVG | LONG | TD |
| DeAndre Carter | 1 | 13 | 13.0 | 13 | 0 |
| Cullen Gillaspia | 1 | 2 | 2.0 | 2 | 0 |
| Team | 2 | 15 | 7.5 | 13 | 0 |
| HOUSTON PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| DeAndre Carter | 1 | 11 | 11.0 | 11 | 0 |
| Team | 1 | 11 | 11.0 | 11 | 0 |
| HOUSTON KICKING | FG | PCT | LONG | XP | PTS |
| Ka'imi Fairbairn | 2/2 | 100.0 | 41 | 0/0 | 6 |
| Team | 2/2 | 100.0 | 41 | 0/0 | 6 |
| HOUSTON PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Bryan Anger | 5 | 216 | 43.2 | 0 | 3 | 56 |
| Team | 5 | 216 | 43.2 | 0 | 3 | 56 |