| ST. LOUIS PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Kellen Clemens | 19/37 | 218 | 5.9 | 1 | 1 | 3-20 | 29.6 | 47.9 |
| Tavon Austin | 0/1 | 0 | 0.0 | 0 | 0 | 0-0 | 0.7 | 39.6 |
| Team | 19/38 | 198 | 5.7 | 1 | 1 | 3-20 | -- | 65.5 |
| ST. LOUIS RUSHING | CAR | YDS | AVG | TD | LONG |
| Zac Stacy | 19 | 72 | 3.8 | 0 | 11 |
| Kellen Clemens | 3 | 21 | 7.0 | 0 | 12 |
| Benny Cunningham | 2 | 16 | 8.0 | 0 | 13 |
| Tavon Austin | 1 | 10 | 10.0 | 0 | 10 |
| Matt Giordano | 1 | -5 | -5.0 | 0 | -5 |
| Team | 26 | 114 | 4.4 | 0 | 13 |
| ST. LOUIS RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Jared Cook | 3 | 49 | 16.3 | 0 | 20 | 6 |
| Stedman Bailey | 3 | 46 | 15.3 | 0 | 17 | 4 |
| Brian Quick | 3 | 41 | 13.7 | 1 | 29 | 4 |
| Chris Givens | 2 | 30 | 15.0 | 0 | 16 | 9 |
| Tavon Austin | 4 | 25 | 6.3 | 0 | 8 | 7 |
| Isaiah Pead | 2 | 17 | 8.5 | 0 | 12 | 3 |
| Austin Pettis | 1 | 11 | 11.0 | 0 | 11 | 3 |
| Zac Stacy | 1 | -1 | -1.0 | 0 | -1 | 2 |
| Team | 19 | 218 | 11.5 | 1 | 29 | 38 |
| ST. LOUIS FUMBLES | FUM | LOST | REC |
| Rodney McLeod Jr. | 0 | 0 | 1 |
| Team | 0 | 0 | 1 |
| ST. LOUIS DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Alec Ogletree | 10 | 7 | 0 | 0 | 0 | 0 | 0 |
| James Laurinaitis | 9 | 6 | 0 | 0 | 0 | 0 | 0 |
| Michael Brockers | 7 | 5 | 2 | 0 | 0 | 2 | 0 |
| T.J. McDonald | 5 | 4 | 0 | 0 | 1 | 0 | 0 |
| Jo-Lonn Dunbar | 4 | 4 | 0 | 0 | 0 | 0 | 0 |
| Rodney McLeod Jr. | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Chris Long | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
| Eugene Sims | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
| Robert Quinn | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
| Trumaine Johnson | 3 | 3 | 0 | 0 | 1 | 0 | 0 |
| Darian Stewart | 3 | 2 | 0 | 0 | 0 | 0 | 0 |
| Kendall Langford | 2 | 2 | 1 | 0 | 1 |
| ST. LOUIS INTERCEPTIONS | INT | YDS | TD |
| ST. LOUIS KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Tavon Austin | 4 | 67 | 16.8 | 20 | 0 |
| Team | 4 | 67 | 16.8 | 20 | 0 |
| ST. LOUIS PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Tavon Austin | 1 | 10 | 10.0 | 10 | 0 |
| Team | 1 | 10 | 10.0 | 10 | 0 |
| ST. LOUIS KICKING | FG | PCT | LONG | XP | PTS |
| Greg Zuerlein | 2/2 | 100.0 | 43 | 1/1 | 7 |
| Team | 2/2 | 100.0 | 43 | 1/1 | 7 |
| ST. LOUIS PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Johnny Hekker | 5 | 244 | 48.8 | 0 | 1 | 54 |
| Team | 5 | 244 | 48.8 | 0 | 1 | 54 |
| SAN FRANCISCO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Colin Kaepernick | 19/28 | 275 | 9.8 | 1 | 0 | 4-20 | 67.3 | 64.6 |
| Team | 19/28 | 255 | 9.8 | 1 | 0 | 4-20 | -- | 111.5 |
| SAN FRANCISCO RUSHING | CAR | YDS | AVG | TD | LONG |
| Frank Gore | 15 | 42 | 2.8 | 1 | 10 |
| Colin Kaepernick | 4 | 21 | 5.3 | 0 | 8 |
| Boobie Dixon | 8 | 13 | 1.6 | 0 | 5 |
| Kendall Hunter | 3 | 7 | 2.3 | 0 | 7 |
| Team | 30 | 83 | 2.8 | 1 | 10 |
| SAN FRANCISCO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Anquan Boldin | 9 | 98 | 10.9 | 0 | 21 | 14 |
| Vernon Davis | 4 | 82 | 20.5 | 1 |
| 1 |
| 0 |
| William Hayes | 2 | 2 | 1 | 0 | 0 | 1 | 0 |
| Janoris Jenkins | 2 | 2 | 0 | 0 | 2 | 0 | 0 |
| Matt Giordano | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Chase Reynolds | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Tavon Austin | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Cody Davis | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Matt Conrath | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Ray-Ray Armstrong | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Team | 66 | 53 | 4 | 0 | 5 | 0 | 0 |
| 23 |
| 5 |
| Michael Crabtree | 2 | 68 | 34.0 | 0 | 60 | 4 |
| Bruce Miller | 2 | 20 | 10.0 | 0 | 21 | 3 |
| Frank Gore | 2 | 7 | 3.5 | 0 | 4 | 2 |
| Team | 19 | 275 | 14.5 | 1 | 60 | 28 |
| SAN FRANCISCO FUMBLES | FUM | LOST | REC |
| Frank Gore | 1 | 1 | 0 |
| LaMike James | 1 | 0 | 0 |
| Team | 2 | 1 | 0 |
| SAN FRANCISCO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| NaVorro Bowman | 11 | 10 | 1 | 0 | 0 | 1 | 0 |
| Donte Whitner | 9 | 7 | 0 | 0 | 0 | 0 | 0 |
| Glenn Dorsey | 6 | 5 | 0 | 0 | 0 | 1 | 0 |
| Eric Reid | 5 | 3 | 0 | 0 | 1 | 0 | 0 |
| Michael Wilhoite | 4 | 4 | 0 | 0 | 0 | 0 | 0 |
| Demarcus Dobbs | 4 | 2 | 0 | 0 | 0 | 0 | 0 |
| Eric Wright | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
| Patrick Willis | 3 | 2 | 1 | 0 | 0 | 1 | 0 |
| C.J. Spillman | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Boobie Dixon | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Aldon Smith | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Kendall Hunter | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Tony Jerod-Eddie | 2 | 2 | 0 | 0 | 0 | 1 | 0 |
| Ray McDonald | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
| Carlos Rogers | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
| Craig Dahl | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Tramaine Brock | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Bruce Miller | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Corey Lemonier | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Nick Moody | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Justin Smith | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
| Dan Skuta | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
| Team | 63 | 53 | 3 | 0 | 2 | 0 | 0 |
| SAN FRANCISCO INTERCEPTIONS | INT | YDS | TD |
| Carlos Rogers | 1 | 3 | 0 |
| Team | 1 | 3 | 0 |
| SAN FRANCISCO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| LaMike James | 1 | 24 | 24.0 | 24 | 0 |
| Team | 1 | 24 | 24.0 | 24 | 0 |
| SAN FRANCISCO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| LaMike James | 2 | 5 | 2.5 | 5 | 0 |
| Team | 2 | 5 | 2.5 | 5 | 0 |
| SAN FRANCISCO KICKING | FG | PCT | LONG | XP | PTS |
| Phil Dawson | 3/3 | 100.0 | 43 | 2/2 | 11 |
| Team | 3/3 | 100.0 | 43 | 2/2 | 11 |
| SAN FRANCISCO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Andy Lee | 4 | 191 | 47.8 | 0 | 2 | 55 |
| Team | 4 | 191 | 47.8 | 0 | 2 | 55 |