| SAN FRANCISCO PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Alex Smith | 15/22 | 206 | 9.4 | 3 | 1 | 0-0 | 95.7 | 118.6 |
| Shaun Hill | 6/11 | 45 | 4.1 | 0 | 0 | 2-13 | 6.2 | 64.6 |
| Team | 21/33 | 238 | 7.6 | 3 | 1 | 2-13 | -- | 104.5 |
| SAN FRANCISCO RUSHING | CAR | YDS | AVG | TD | LONG |
| Frank Gore | 13 | 32 | 2.5 | 0 | 9 |
| Alex Smith | 2 | 16 | 8.0 | 0 | 11 |
| Josh Morgan | 1 | 6 | 6.0 | 0 | 6 |
| Glen Coffee | 2 | 3 | 1.5 | 0 | 2 |
| Shaun Hill | 1 | 2 | 2.0 | 0 | 2 |
| Team | 19 | 59 | 3.1 | 0 | 11 |
| SAN FRANCISCO RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Vernon Davis | 7 | 93 | 13.3 | 3 | 29 | 11 |
| Josh Morgan | 4 | 62 | 15.5 | 0 | 23 | 4 |
| Michael Crabtree | 5 | 56 | 11.2 | 0 | 18 | 6 |
| Isaac Bruce | 2 | 23 | 11.5 | 0 | 22 | 6 |
| Frank Gore | 2 | 15 | 7.5 | 0 | 9 | 3 |
| Delanie Walker | 1 | 2 | 2.0 | 0 | 2 | 1 |
| Team | 21 | 251 | 12.0 | 3 | 29 | 31 |
| SAN FRANCISCO FUMBLES | FUM | LOST | REC |
| Arnaz Battle | 1 | 1 | 0 |
| Dashon Goldson | 0 | 0 | 1 |
| Team | 1 | 1 | 1 |
| SAN FRANCISCO DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Justin Smith | 10 | 8 | 0 | 0 | 0 | 0 | 0 |
| Patrick Willis | 10 | 8 | 0 | 0 | 1 | 0 | 0 |
| Dashon Goldson | 9 | 6 | 0 | 0 | 0 | 0 | 0 |
| Marcus Hudson | 7 | 6 | 0 | 0 | 0 | 0 | 0 |
| Manny Lawson | 5 | 4 | 1 | 0 | 0 | 0 | 0 |
| Nate Clements | 4 | 4 | 0 | 0 | 1 | 0 | 0 |
| Scott McKillop | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Mark Roman | 3 | 3 | 0 | 0 | 1 | 0 | 0 |
| Shawntae Spencer | 3 | 2 | 0 | 0 | 1 | 0 | 0 |
| Ahmad Brooks | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| Takeo Spikes | 2 | 1 | 0 | 0 | 0 | 0 | 0 |
| Delanie Walker | 2 | 1 | 0 | 0 | 0 |
| SAN FRANCISCO INTERCEPTIONS | INT | YDS | TD |
| SAN FRANCISCO KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Michael Robinson | 3 | 94 | 31.3 | 40 | 0 |
| Team | 3 | 94 | 31.3 | 40 | 0 |
| SAN FRANCISCO PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Arnaz Battle | 1 | 0 | 0.0 | 0 | 0 |
| Team | 1 | 0 | 0.0 | 0 | 0 |
| SAN FRANCISCO KICKING | FG | PCT | LONG | XP | PTS |
| Joe Nedney | 0/0 | 0.0 | 0 | 3/3 | 3 |
| Team | 0/0 | 0.0 | 0 | 3/3 | 3 |
| SAN FRANCISCO PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Andy Lee | 5 | 241 | 48.2 | 0 | 0 | 52 |
| Team | 5 | 241 | 48.2 | 0 | 0 | 52 |
| HOUSTON PASSING | C/ATT | YDS | AVG | TD | INT | SACKS | QBR | RTG |
| Matt Schaub | 20/30 | 264 | 8.8 | 2 | 0 | 2-18 | 78.4 | 116.5 |
| Team | 20/30 | 246 | 8.8 | 2 | 0 | 2-18 | -- | 116.5 |
| HOUSTON RUSHING | CAR | YDS | AVG | TD | LONG |
| Steve Slaton | 18 | 67 | 3.7 | 1 | 31 |
| Chris Brown | 4 | 14 | 3.5 | 0 | 13 |
| Matt Schaub | 5 | 9 | 1.8 | 0 | 4 |
| Team | 27 | 90 | 3.3 | 1 | 31 |
| HOUSTON RECEIVING | REC | YDS | AVG | TD | LONG | TGTS |
| Owen Daniels | 7 | 123 | 17.6 | 1 | 42 | 9 |
| Andre Johnson | 2 | 62 | 31.0 | 0 | 44 | 4 |
| Kevin Walter | 3 | 29 | 9.7 | 0 | 14 | 3 |
| 0 |
| 0 |
| Matt Wilhelm | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Arnaz Battle | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Michael Robinson | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Parys Haralson | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Josh Morgan | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Demetric Evans | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Marques Harris | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Tarell Brown | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Kentwan Balmer | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Team | 70 | 53 | 2 | 0 | 4 | 0 | 0 |
| 4 |
| 22 |
| 5.5 |
| 1 |
| 11 |
| 6 |
| Andre Davis | 1 | 14 | 14.0 | 0 | 14 | 2 |
| David Anderson | 2 | 10 | 5.0 | 0 | 8 | 2 |
| Chris Brown | 1 | 4 | 4.0 | 0 | 4 | 1 |
| Team | 20 | 264 | 13.2 | 2 | 44 | 27 |
| HOUSTON FUMBLES | FUM | LOST | REC |
| Steve Slaton | 1 | 1 | 0 |
| Andre Davis | 0 | 0 | 1 |
| Team | 1 | 1 | 1 |
| HOUSTON DEFENSE | TOT | SOLO | SACKS | TFL | PD | QB HTS | TD |
| Brian Cushing | 8 | 5 | 0 | 0 | 1 | 0 | 0 |
| Jacques Reeves | 7 | 6 | 0 | 0 | 0 | 0 | 0 |
| Zac Diles | 7 | 4 | 0 | 0 | 0 | 0 | 0 |
| DeMeco Ryans | 6 | 6 | 0 | 0 | 0 | 0 | 0 |
| Dunta Robinson | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Bernard Pollard | 4 | 3 | 0 | 0 | 0 | 0 | 0 |
| Mario Williams | 3 | 2 | 1 | 0 | 0 | 0 | 0 |
| Eugene Wilson | 3 | 2 | 0 | 0 | 2 | 0 | 0 |
| Jeff Zgonina | 2 | 2 | 1 | 0 | 0 | 0 | 0 |
| Shaun Cody | 2 | 2 | 0 | 0 | 0 | 0 | 0 |
| Kevin Bentley | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Antonio Smith | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
| Joel Dreessen | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| John Busing | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Amobi Okoye | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Duane Brown | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Connor Barwin | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| Glover Quin | 1 | 1 | 0 | 0 | 1 | 0 | 0 |
| Dominique Barber | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| Team | 55 | 43 | 2 | 0 | 5 | 0 | 0 |
| HOUSTON INTERCEPTIONS | INT | YDS | TD |
| Eugene Wilson | 1 | 16 | 0 |
| Team | 1 | 16 | 0 |
| HOUSTON KICK RETURNS | NO | YDS | AVG | LONG | TD |
| Andre Davis | 4 | 75 | 18.8 | 20 | 0 |
| Team | 4 | 75 | 18.8 | 20 | 0 |
| HOUSTON PUNT RETURNS | NO | YDS | AVG | LONG | TD |
| Jacoby Jones | 5 | 26 | 5.2 | 12 | 0 |
| Team | 5 | 26 | 5.2 | 12 | 0 |
| HOUSTON KICKING | FG | PCT | LONG | XP | PTS |
| Kris Brown | 1/1 | 100.0 | 50 | 3/3 | 6 |
| Team | 1/1 | 100.0 | 50 | 3/3 | 6 |
| HOUSTON PUNTING | NO | YDS | AVG | TB | In 20 | LONG |
| Matt Turk | 5 | 186 | 37.2 | 0 | 4 | 45 |
| Team | 5 | 186 | 37.2 | 0 | 4 | 45 |