Brandon McCarthy · Roost| Aug 15 | @ TB | L 5-0 | 6.1 | 7 | 4 | 2 | 0 | 1 | 7 | 14 | 6 | 110 | 28 | 53.0 | L(4-2) | - | 2.30 |
| Aug 9 | vs CLE | L 3-0 | 6.1 | 7 | 2 | 2 | 1 | 0 | 8 | 7 | 11 | 90 | 26 | 59.0 | L(4-1) | - | 2.21 |
| Aug 4 | vs DET | W 2-1 | 5.2 | 5 | 1 | 0 | 0 | 2 | 8 | 10 | 5 | 116 | 25 | 63.0 | W(4-0) | - | 2.08 |
| Jul 29 | @ TEX | W 12-11 | 6.0 | 10 | 4 | 4 | 1 | 1 | 3 | 12 | 12 | 108 | 28 | 38.0 | W(3-0) | - | 2.55 |
| Jul 24 | vs TEX | W 4-2 | 6.0 | 4 | 1 | 1 | 0 | 2 | 5 | 7 | 9 | 109 | 23 | 63.0 | W(2-0) | - | 1.45 |
| Jul 19 | vs CIN | W 7-1 | 6.0 | 6 | 1 | 1 | 1 | 0 | 9 | 7 | 8 | 99 | 24 | 65.0 | W(1-0) | - | 1.42 |
| Jul 9 | @ CLE | W 5-4 F/14 | 6.2 | 9 | 4 | 1 | 0 | 1 | 3 | 15 | 10 | 101 | 29 | 48.0 | - | - | 1.35 |
| Jul 3 | @ PIT | W 10-2 | 5.2 | 8 | 2 | 2 | 0 | 2 | 6 | 8 | 8 | 100 | 24 | 49.0 | W(3-10) | - | 5.01 |
| Jun 27 | @ SD | W 2-1 | 7.0 | 6 | 1 | 1 | 0 | 0 | 7 | 10 | 8 | 94 | 26 | 68.0 | W(2-10) | - | 5.11 |
| Jun 21 | vs SF | L 6-4 | 5.0 | 10 | 5 | 5 | 0 | 1 | 2 | 14 | 9 | 85 | 27 | 28.0 | L(1-10) | - | 5.38 |
| Jun 16 | vs MIL | L 9-3 | 7.0 | 7 | 3 | 3 | 1 | 1 | 2 | 12 | 11 | 88 | 26 | 52.0 | - | - | 5.18 |
| Jun 11 | @ HOU | L 5-1 | 6.0 | 8 | 5 | 5 | 2 | 2 | 4 | 12 | 8 | 86 | 26 | 38.0 | L(1-9) | - | 5.29 |
| Jun 6 | vs ATL | L 5-2 | 6.1 | 9 | 3 | 3 | 1 | 1 | 9 | 12 | 7 | 104 | 29 | 51.0 | L(1-8) | - | 5.13 |
| May 31 | vs CIN | L 5-0 | 4.1 | 9 | 5 | 5 | 0 | 1 | 4 | 11 | 5 | 77 | 21 | 28.0 | L(1-7) | - | 5.20 |
| May 26 | vs SD | W 7-5 | 6.2 | 9 | 5 | 5 | 2 | 0 | 4 | 12 | 11 | 82 | 27 | 40.0 | - | - | 4.87 |
| May 21 | @ STL | L 3-2 F/12 | 6.0 | 7 | 1 | 1 | 0 | 2 | 3 | 12 | 8 | 99 | 26 | 55.0 | - | - | 4.67 |
| May 14 | vs WSH | L 5-1 | 8.0 | 2 | 1 | 1 | 1 | 0 | 7 | 14 | 6 | 101 | 27 | 81.0 | - | - | 5.01 |
| May 9 | @ CHW | L 9-3 | 3.1 | 9 | 7 | 7 | 1 | 0 | 5 | 4 | 10 | 64 | 19 | 19.0 | L(1-6) | - | 5.66 |
| May 3 | @ SD | W 4-3 | 7.0 | 3 | 0 | 0 | 0 | 1 | 6 | 9 | 8 | 88 | 24 | 76.0 | W(1-5) | - | 4.67 |
| Apr 27 | vs PHI | L 2-0 | 7.0 | 7 | 2 | 2 | 0 | 1 | 12 | 7 | 8 | 103 | 28 | 66.0 | L(0-5) | - | 5.54 |
| Apr 22 | @ CHC | L 9-2 | 5.0 | 7 | 5 | 1 | 1 | 2 | 6 | 7 | 10 | 99 | 25 | 45.0 | L(0-4) | - | 6.23 |
| Apr 16 | vs NYM | L 5-2 | 5.2 | 7 | 3 | 3 | 1 | 3 | 5 | 8 | 11 | 104 | 27 | 45.0 | L(0-3) | - | 7.11 |
| Apr 11 | vs LAD | L 6-0 | 7.0 | 10 | 6 | 6 | 1 | 1 | 4 | 18 | 8 | 96 | 31 | 36.0 | L(0-2) | - | 7.78 |
| Apr 5 | @ COL | L 9-4 | 6.0 | 7 | 6 | 6 | 3 | 1 | 3 | 16 | 6 | 71 | 26 | 36.0 | L(0-1) | - | 7.82 |
| Mar 31 | vs SF | L 9-8 | 6.2 | 6 | 5 | 5 | 1 | 1 | 4 | 11 | 11 | 94 | 27 | 45.0 | - | - | 6.75 |
