Jose Quintana · Roost| Aug 20 | @ LAA | W 8-2 | 6.0 | 8 | 2 | 2 | 0 | 2 | 3 | 10 | 12 | 102 | 27 | 49.0 | W(7-10) | - | 3.60 |
| Aug 15 | vs CHC | L 6-3 | 6.0 | 7 | 3 | 3 | 0 | 1 | 4 | 4 | 16 | 110 | 25 | 49.0 | L(6-10) | - | 3.62 |
| Aug 9 | @ KC | L 5-4 | 6.2 | 8 | 4 | 4 | 1 | 2 | 4 | 10 | 13 | 108 | 29 | 44.0 | - | - | 3.59 |
| Aug 3 | vs TB | L 5-4 | 6.0 | 7 | 2 | 2 | 0 | 1 | 7 | 11 | 7 | 109 | 27 | 56.0 | - | - | 3.50 |
| Jul 29 | @ BOS | W 9-2 | 6.1 | 6 | 2 | 2 | 1 | 1 | 3 | 11 | 9 | 104 | 24 | 55.0 | W(6-9) | - | 3.52 |
| Jul 24 | @ CLE | W 6-0 | 9.0 | 7 | 0 | 0 | 0 | 0 | 8 | 17 | 6 | 120 | 31 | 81.0 | W(5-9) | - | 3.56 |
| Jul 18 | vs KC | L 7-6 F/13 | 5.1 | 10 | 4 | 4 | 0 | 1 | 4 | 9 | 12 | 107 | 27 | 35.0 | - | - | 3.83 |
| Jul 12 | @ CHC | L 3-1 | 7.1 | 8 | 3 | 3 | 1 | 0 | 9 | 8 | 11 | 101 | 29 | 59.0 | L(4-9) | - | 3.69 |
| Jul 7 | vs TOR | L 2-1 | 8.0 | 4 | 2 | 2 | 1 | 0 | 8 | 16 | 4 | 114 | 28 | 74.0 | L(4-8) | - | 3.69 |
| Jul 1 | @ STL | W 7-1 | 6.0 | 6 | 1 | 1 | 0 | 0 | 8 | 4 | 12 | 94 | 24 | 64.0 | W(4-7) | - | 3.81 |
| Jun 26 | @ DET | L 5-4 | 6.0 | 11 | 3 | 3 | 0 | 0 | 3 | 9 | 15 | 93 | 27 | 41.0 | - | - | 3.95 |
| Jun 21 | vs TEX | W 3-2 F/11 | 7.0 | 5 | 2 | 2 | 2 | 2 | 5 | 8 | 14 | 108 | 29 | 62.0 | - | - | 3.92 |
| Jun 16 | @ PIT | L 3-0 | 6.0 | 9 | 3 | 3 | 2 | 1 | 6 | 10 | 9 | 112 | 27 | 47.0 | L(3-7) | - | 4.03 |
| Jun 10 | vs HOU | W 4-1 | 7.0 | 6 | 1 | 1 | 0 | 2 | 3 | 11 | 15 | 104 | 31 | 62.0 | W(3-6) | - | 4.00 |
| Jun 5 | vs DET | W 4-3 F/11 | 7.0 | 9 | 3 | 3 | 0 | 2 | 4 | 12 | 11 | 92 | 29 | 49.0 | - | - | 4.28 |
| May 30 | @ HOU | L 3-0 | 6.1 | 5 | 1 | 1 | 0 | 4 | 7 | 8 | 7 | 110 | 26 | 62.0 | L(2-6) | - | 4.33 |
| May 24 | vs MIN | L 8-1 | 6.0 | 7 | 7 | 6 | 1 | 1 | 5 | 11 | 10 | 101 | 27 | 36.0 | L(2-5) | - | 4.67 |
| May 19 | vs CLE | L 3-1 | 7.0 | 8 | 2 | 2 | 0 | 4 | 4 | 12 | 11 | 112 | 32 | 53.0 | L(2-4) | - | 4.13 |
| May 13 | @ MIL | W 4-2 | 7.0 | 4 | 1 | 1 | 0 | 1 | 10 | 9 | 5 | 112 | 25 | 74.0 | W(2-3) | - | 4.39 |
| May 7 | vs DET | L 4-1 | 5.0 | 4 | 2 | 2 | 0 | 2 | 8 | 4 | 7 | 107 | 22 | 57.0 | L(1-3) | - | 5.03 |
| May 1 | @ MIN | L 1-0 | 7.0 | 6 | 1 | 1 | 0 | 2 | 5 | 13 | 7 | 105 | 27 | 64.0 | L(1-2) | - | 5.28 |
| Apr 26 | vs KC | W 3-2 | 7.0 | 7 | 2 | 2 | 0 | 1 | 5 | 10 | 9 | 98 | 25 | 59.0 | - | - | 6.55 |
| Apr 19 | @ DET | L 9-1 | 4.0 | 10 | 9 | 9 | 2 | 1 | 1 | 3 | 17 | 93 | 22 | 6.0 | L(1-1) | - | 8.40 |
| Apr 14 | @ CLE | W 4-1 | 6.0 | 3 | 1 | 0 | 0 | 2 | 6 | 6 | 8 | 104 | 23 | 68.0 | W(1-0) | - | 4.09 |
| Apr 8 | @ KC | L 7-5 | 5.0 | 9 | 5 | 5 | 1 | 1 | 4 | 7 | 13 | 102 | 27 | 32.0 | - | - | 9.00 |
