Jose Quintana · Roost| Aug 25 | vs SEA | W 5-4 | 5.2 | 5 | 3 | 3 | 1 | 4 | 4 | 8 | 10 | 112 | 26 | 47.0 | - | - | 2.86 |
| Aug 19 | @ KC | L 5-2 | 7.0 | 9 | 2 | 2 | 0 | 4 | 5 | 14 | 7 | 110 | 30 | 52.0 | - | - | 2.76 |
| Aug 14 | @ TOR | W 3-2 | 6.2 | 8 | 2 | 2 | 0 | 2 | 4 | 12 | 11 | 105 | 29 | 52.0 | W(5-2) | - | 2.77 |
| Aug 8 | vs KC | L 2-1 | 7.0 | 5 | 2 | 2 | 2 | 2 | 5 | 11 | 10 | 107 | 28 | 62.0 | L(4-2) | - | 2.78 |
| Jul 30 | @ MIN | L 7-6 | 7.0 | 10 | 6 | 4 | 0 | 1 | 0 | 14 | 14 | 99 | 29 | 36.0 | - | - | 2.80 |
| Jul 24 | vs MIN | W 11-4 | 6.1 | 8 | 4 | 4 | 2 | 1 | 1 | 13 | 12 | 108 | 28 | 41.0 | - | - | 2.58 |
| Jul 19 | @ BOS | L 3-1 | 8.0 | 5 | 0 | 0 | 0 | 0 | 2 | 14 | 12 | 103 | 28 | 74.0 | - | - | 2.30 |
| Jul 13 | @ KC | W 9-8 F/14 | 5.0 | 8 | 5 | 5 | 2 | 3 | 4 | 9 | 10 | 108 | 26 | 32.0 | - | - | 2.60 |
| Jul 5 | vs TEX | W 2-1 | 8.0 | 2 | 1 | 1 | 0 | 1 | 8 | 9 | 7 | 113 | 26 | 81.0 | W(4-1) | - | 2.04 |
| Jun 29 | @ NYY | W 14-7 | 6.0 | 8 | 6 | 6 | 1 | 3 | 5 | 12 | 8 | 101 | 28 | 34.0 | W(3-1) | - | 2.19 |
| Jun 24 | vs MIL | W 1-0 F/10 | 8.0 | 6 | 0 | 0 | 0 | 0 | 4 | 11 | 14 | 101 | 29 | 74.0 | - | - | 1.25 |
| Jun 17 | @ LAD | L 2-1 F/10 | 8.0 | 5 | 0 | 0 | 0 | 0 | 6 | 12 | 8 | 77 | 26 | 78.0 | - | - | 1.53 |
| Jun 12 | @ STL | W 6-1 | 5.1 | 10 | 1 | 1 | 0 | 0 | 4 | 8 | 12 | 76 | 24 | 48.0 | W(2-1) | - | 1.98 |
| Jun 6 | vs TOR | L 4-0 | 6.0 | 9 | 2 | 2 | 1 | 1 | 1 | 11 | 11 | 92 | 24 | 46.0 | L(1-1) | - | 2.05 |
| Jun 2 | vs SEA | L 10-8 F/12 | 0.2 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 3 | 2 | 0.0 | - | - | 1.69 |
| May 30 | @ TB | W 4-3 | 3.2 | 1 | 1 | 1 | 1 | 0 | 2 | 5 | 5 | 51 | 12 | 57.0 | - | - | 1.76 |
| May 25 | vs CLE | W 9-3 | 6.0 | 4 | 2 | 2 | 0 | 3 | 4 | 5 | 13 | 107 | 25 | 57.0 | W(1-0) | - | 1.54 |
| May 7 | @ CLE | L 8-6 | 5.2 | 1 | 0 | 0 | 0 | 2 | 3 | 4 | 11 | 80 | 20 | 0.0 | - | - | 0.00 |